| 1 | BAKER BROS. ADVISORS LP | $904M | 1 | | |
| 2 | PERCEPTIVE ADVISORS LLC | $357M | 1 | | |
| 3 | RTW INVESTMENTS, LP | $347M | 1 | | |
| 4 | BlackRock, Inc. | $309M | 1 | | |
| 5 | NEA Management Company, LLC | $261M | 1 | | |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | $203M | 1 | | |
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | $196M | 1 | | |
| 8 | STATE STREET CORP | $173M | 1 | | |
| 9 | MORGAN STANLEY | $154M | 1 | | |
| 10 | Soleus Capital Management, L.P. | $147M | 1 | | |
| 11 | TANG CAPITAL MANAGEMENT LLC | $120M | 1 | | |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | $102M | 1 | | |
| 13 | TORONTO DOMINION BANK | $101M | 1 | | |
| 14 | BANK OF AMERICA CORP /DE/ | $81.5M | 1 | | |
| 15 | APIS CAPITAL ADVISORS, LLC | $58.8M | 1 | | |
| 16 | Artisan Partners Limited Partnership | $52.2M | 1 | | |
| 17 | WELLINGTON MANAGEMENT GROUP LLP | $49.0M | 1 | | |
| 18 | ALLIANCEBERNSTEIN L.P. | $46.3M | 1 | | |
| 19 | Holocene Advisors, LP | $42.2M | 1 | | |
| 20 | Sofinnova Investments, Inc. | $41.8M | 1 | | |
| 21 | SILVERARC CAPITAL MANAGEMENT, LLC | $40.9M | 1 | | |
| 22 | NORTHERN TRUST CORP | $36.4M | 1 | | |
| 23 | CAPITOLIS LIQUID GLOBAL MARKETS LLC | $36.1M | 1 | | |
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $33.5M | 1 | | |
| 25 | VANGUARD PORTFOLIO MANAGEMENT LLC | $33.2M | 1 | | |
| 26 | Saturn V Capital Management LP | $32.2M | 1 | | |
| 27 | Point72 Asset Management, L.P. | $32.0M | 1 | | |
| 28 | PFIZER INC | $31.3M | 1 | | |
| 29 | VANGUARD FIDUCIARY TRUST CO | $28.9M | 1 | | |
| 30 | EVENTIDE ASSET MANAGEMENT, LLC | $27.8M | 1 | | |
| 31 | DRIEHAUS CAPITAL MANAGEMENT LLC | $27.6M | 1 | | |
| 32 | Focus Partners Wealth | $26.6M | 1 | | |
| 33 | JENNISON ASSOCIATES LLC | $26.4M | 1 | | |
| 34 | Candriam S.C.A. | $26.3M | 1 | | |
| 35 | Boxer Capital Management, LLC | $25.7M | 1 | | |
| 36 | UBS Group AG | $25.1M | 1 | | |
| 37 | First Turn Management, LLC | $24.0M | 1 | | |
| 38 | Sio Capital Management, LLC | $22.1M | 1 | | |
| 39 | Hennion & Walsh Asset Management, Inc. | $20.8M | 1 | | |
| 40 | Ensign Peak Advisors, Inc | $17.0M | 1 | | |
| 41 | Woodline Partners LP | $16.6M | 1 | | |
| 42 | VOYA INVESTMENT MANAGEMENT LLC | $15.2M | 1 | | |
| 43 | CITADEL ADVISORS LLC | $15.1M | 1 | | |
| 44 | STEMPOINT CAPITAL LP | $13.7M | 1 | | |
| 45 | FEDERATED HERMES, INC. | $13.6M | 1 | | |
| 46 | RAYMOND JAMES FINANCIAL INC | $12.8M | 1 | | |
| 47 | Walleye Capital LLC | $12.1M | 1 | | |
| 48 | NAN FUNG TRINITY (HK) Ltd | $11.8M | 1 | | |
| 49 | AMERIPRISE FINANCIAL INC | $11.3M | 1 | | |
| 50 | Patient Square Capital LP | $10.8M | 1 | | |
| 51 | Bank of New York Mellon Corp | $10.7M | 1 | | |
| 52 | Clearbridge Investments, LLC | $10.5M | 1 | | |
| 53 | ACT CAPITAL MANAGEMENT, LLC | $10.5M | 1 | | |
| 54 | Invesco Ltd. | $10.4M | 1 | | |
| 55 | Granahan Investment Management, LLC | $10.1M | 1 | | |
| 56 | TD ASSET MANAGEMENT INC | $9.6M | 1 | | |
| 57 | Integral Health Asset Management, LLC | $9.1M | 1 | | |
| 58 | Nuveen, LLC | $8.7M | 1 | | |
| 59 | Atom Investors LP | $8.7M | 1 | | |
| 60 | Alyeska Investment Group, L.P. | $8.6M | 1 | | |
| 61 | Freestone Grove Partners LP | $8.1M | 1 | | |
| 62 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | $7.7M | 1 | | |
| 63 | CITIGROUP INC | $7.6M | 1 | | |
| 64 | BALYASNY ASSET MANAGEMENT L.P. | $7.4M | 1 | | |
| 65 | Harvest Investment Services, LLC | $6.2M | 1 | | |
| 66 | GAGNON SECURITIES LLC | $6.1M | 1 | | |
| 67 | BNP Paribas Asset Management Holding S.A. | $6.1M | 1 | | |
| 68 | Connor, Clark & Lunn Investment Management Ltd. | $5.9M | 1 | | |
| 69 | PRUDENTIAL FINANCIAL INC | $5.8M | 1 | | |
| 70 | NEW YORK STATE COMMON RETIREMENT FUND | $5.6M | 1 | | |
| 71 | E Fund Management Co., Ltd. | $5.3M | 1 | | |
| 72 | Tidal Investments LLC | $5.2M | 1 | | |
| 73 | TEMA ETFS LLC | $5.2M | 1 | | |
| 74 | Atle Fund Management AB | $5.1M | 1 | | |
| 75 | Man Group plc | $5.0M | 1 | | |
| 76 | RHUMBLINE ADVISERS | $4.9M | 1 | | |
| 77 | Swiss National Bank | $4.7M | 1 | | |
| 78 | Rafferty Asset Management, LLC | $4.4M | 1 | | |
| 79 | ALPS ADVISORS INC | $4.3M | 1 | | |
| 80 | FMR LLC | $4.2M | 1 | | |
| 81 | JNBA Financial Advisors | $4.1M | 1 | | |
| 82 | Creative Planning | $4.0M | 1 | | |
| 83 | VICTORY CAPITAL MANAGEMENT INC | $4.0M | 1 | | |
| 84 | Schonfeld Strategic Advisors LLC | $4.0M | 1 | | |
| 85 | Qube Research & Technologies Ltd | $3.8M | 1 | | |
| 86 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $3.5M | 1 | | |
| 87 | DEUTSCHE BANK AG\ | $3.5M | 1 | | |
| 88 | BRAIDWELL LP | $3.3M | 1 | | |
| 89 | BARCLAYS PLC | $3.3M | 1 | | |
| 90 | Nan Fung Group Holdings Ltd | $3.2M | 1 | | |
| 91 | Accredited Investors Inc. | $3.1M | 1 | | |
| 92 | Squarepoint Ops LLC | $2.7M | 1 | | |
| 93 | Nicholas Investment Partners, LP | $2.5M | 1 | | |
| 94 | Quantinno Capital Management LP | $2.5M | 1 | | |
| 95 | SummitTX Capital, L.P. | $2.4M | 1 | | |
| 96 | D. E. Shaw & Co., Inc. | $2.4M | 1 | | |
| 97 | WELLS FARGO & COMPANY/MN | $2.2M | 1 | | |
| 98 | MetLife Investment Management, LLC | $2.2M | 1 | | |
| 99 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $2.2M | 1 | | |
| 100 | AQR CAPITAL MANAGEMENT LLC | $2.0M | 1 | | |
| 101 | STATE OF WISCONSIN INVESTMENT BOARD | $2.0M | 1 | | |
| 102 | PROFUND ADVISORS LLC | $2.0M | 1 | | |
| 103 | Legal & General Group Plc | $2.0M | 1 | | |
| 104 | Vanguard Global Advisers, LLC | $2.0M | 1 | | |
| 105 | POLEN CAPITAL MANAGEMENT LLC | $2.0M | 1 | | |
| 106 | FRANKLIN RESOURCES INC | $1.9M | 1 | | |
| 107 | WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $1.8M | 1 | | |
| 108 | Artia Global Partners LP | $1.8M | 1 | | |
| 109 | MYDA Advisors LLC | $1.7M | 1 | | |
| 110 | XTX Topco Ltd | $1.7M | 1 | | |
| 111 | SEI INVESTMENTS CO | $1.6M | 1 | | |
| 112 | LPL Financial LLC | $1.6M | 1 | | |
| 113 | VANGUARD ASSET MANAGEMENT, Ltd | $1.6M | 1 | | |
| 114 | Kestra Advisory Services, LLC | $1.6M | 1 | | |
| 115 | HighVista Strategies LLC | $1.5M | 1 | | |
| 116 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1.4M | 1 | | |
| 117 | COFG Advisors, LLC | $1.4M | 1 | | |
| 118 | INTEGRITY ALLIANCE, LLC. | $1.3M | 1 | | |
| 119 | IMC-Chicago, LLC | $1.2M | 1 | | |
| 120 | Janus Henderson Group Ltd. | $1.1M | 1 | | |
| 121 | INTECH INVESTMENT MANAGEMENT LLC | $1.1M | 1 | | |
| 122 | Odyssean, LLC | $1.0M | 1 | | |
| 123 | Focus Financial Network, Inc. | $1.0M | 1 | | |
| 124 | GUGGENHEIM CAPITAL LLC | $979K | 1 | | |
| 125 | Zurcher Kantonalbank (Zurich Cantonalbank) | $947K | 1 | | |
| 126 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $927K | 1 | | |
| 127 | Jain Global LLC | $910K | 1 | | |
| 128 | ROYAL BANK OF CANADA | $898K | 1 | | |
| 129 | Swiss Life Asset Management Ltd | $882K | 1 | | |
| 130 | Cresset Asset Management, LLC | $844K | 1 | | |
| 131 | Ellsworth Advisors, LLC | $824K | 1 | | |
| 132 | State of New Jersey Common Pension Fund D | $812K | 1 | | |
| 133 | Shay Capital LLC | $799K | 1 | | |
| 134 | LEVEL FOUR ADVISORY SERVICES, LLC | $732K | 1 | | |
| 135 | SBI Okasan Asset Management Co.Ltd. | $704K | 1 | | |
| 136 | Seven Fleet Capital Management LP | $685K | 1 | | |
| 137 | SCHWARZ DYGOS WHEELER INVESTMENT ADVISORS LLC | $678K | 1 | | |
| 138 | Arizona State Retirement System | $653K | 1 | | |
| 139 | GREAT VALLEY ADVISOR GROUP, INC. | $625K | 1 | | |
| 140 | PERKINS CAPITAL MANAGEMENT INC | $616K | 1 | | |
| 141 | Vanguard Investments Australia, Ltd. | $609K | 1 | | |
| 142 | DIADEMA PARTNERS LP | $607K | 1 | | |
| 143 | AlTi Global, Inc. | $603K | 1 | | |
| 144 | Red Door Wealth Management, LLC | $591K | 1 | | |
| 145 | OPPENHEIMER & CO INC | $586K | 1 | | |
| 146 | ProShare Advisors LLC | $581K | 1 | | |
| 147 | CHOREO, LLC | $559K | 1 | | |
| 148 | NorthRock Partners, LLC | $554K | 1 | | |
| 149 | Persistent Asset Partners Ltd | $553K | 1 | | |
| 150 | Inscription Capital, LLC | $538K | 1 | | |
| 151 | KLP KAPITALFORVALTNING AS | $525K | 1 | | |
| 152 | M&T BANK CORP | $520K | 1 | | |
| 153 | Hudson Bay Capital Management LP | $515K | 1 | | |
| 154 | Sequoia Financial Advisors, LLC | $495K | 1 | | |
| 155 | MERCER GLOBAL ADVISORS INC /ADV | $489K | 1 | | |
| 156 | Simplicity Wealth,LLC | $476K | 1 | | |
| 157 | FARALLON CAPITAL MANAGEMENT, L.L.C. | $457K | 1 | | |
| 158 | KVP Capital Advisors, LP | $457K | 1 | | |
| 159 | ExodusPoint Capital Management, LP | $449K | 1 | | |
| 160 | MILLENNIUM MANAGEMENT LLC | $448K | 1 | | |
| 161 | Legato Capital Management LLC | $433K | 1 | | |
| 162 | Allianz Asset Management GmbH | $422K | 1 | | |
| 163 | Cinctive Capital Management LP | $415K | 1 | | |
| 164 | ENVESTNET ASSET MANAGEMENT INC | $397K | 1 | | |
| 165 | CIBC Bancorp USA Inc. | $385K | 1 | | |
| 166 | XPONANCE LLC | $365K | 1 | | |
| 167 | Pictet Asset Management Holding SA | $358K | 1 | | |
| 168 | FOCUSED ALPHA, LLC | $356K | 1 | | |
| 169 | OneDigital Investment Advisors LLC | $343K | 1 | | |
| 170 | Tower Research Capital LLC (TRC) | $338K | 1 | | |
| 171 | WINTON GROUP Ltd | $330K | 1 | | |
| 172 | Ameritas Investment Partners, Inc. | $328K | 1 | | |
| 173 | Roundview Capital LLC | $317K | 1 | | |
| 174 | TEACHER RETIREMENT SYSTEM OF TEXAS | $307K | 1 | | |
| 175 | Saxony Capital Management, LLC | $307K | 1 | | |
| 176 | MANGROVE PARTNERS IM, LLC | $306K | 1 | | |
| 177 | Magnus Financial Group LLC | $301K | 1 | | |
| 178 | Virtus Investment Advisers, LLC | $296K | 1 | | |
| 179 | PRINCIPAL FINANCIAL GROUP INC | $282K | 1 | | |
| 180 | JANE STREET GROUP, LLC | $264K | 1 | | |
| 181 | Universal- Beteiligungs- und Servicegesellschaft mbH | $242K | 1 | | |
| 182 | Perbak Capital Partners LLP | $236K | 1 | | |
| 183 | Abel Hall, LLC | $236K | 1 | | |
| 184 | Vanguard Personalized Indexing Management, LLC | $233K | 1 | | |
| 185 | Tradition Wealth Management, LLC | $231K | 1 | | |
| 186 | Keystone Wealth Services, LLC | $228K | 1 | | |
| 187 | PSP Research LLC | $228K | 1 | | |
| 188 | STIFEL FINANCIAL CORP | $226K | 1 | | |
| 189 | ABS Direct Equity Fund LLC | $217K | 1 | | |
| 190 | Murphy Pohlad Asset Management LLC | $217K | 1 | | |
| 191 | CIBC Asset Management Inc | $212K | 1 | | |
| 192 | GREENLEAF TRUST | $206K | 1 | | |
| 193 | Quantbot Technologies LP | $196K | 1 | | |
| 194 | OSAIC HOLDINGS, INC. | $141K | 1 | | |
| 195 | GROUP ONE TRADING LLC | $119K | 1 | | |
| 196 | NISA INVESTMENT ADVISORS, LLC | $104K | 1 | | |
| 197 | US BANCORP \DE\ | $84.6K | 1 | | |
| 198 | Rockefeller Capital Management L.P. | $69.4K | 1 | | |
| 199 | Pinnacle Wealth Planning Services, Inc. | $57.2K | 1 | | |
| 200 | Caitong International Asset Management Co., Ltd | $52.8K | 1 | | |
| 201 | LORD, ABBETT & CO. LLC | $50.1K | 1 | | |
| 202 | CWM, LLC | $41.3K | 1 | | |
| 203 | Kemnay Advisory Services Inc. | $39.5K | 1 | | |
| 204 | Bayforest Capital Ltd | $39.0K | 1 | | |
| 205 | Arax Advisory Partners | $35.3K | 1 | | |
| 206 | Sterling Capital Management LLC | $31.4K | 1 | | |
| 207 | SIGNATUREFD, LLC | $25.3K | 1 | | |
| 208 | Optiver Holding B.V. | $24.7K | 1 | | |
| 209 | QUADRANT CAPITAL GROUP LLC | $23.5K | 1 | | |
| 210 | Financial Perspectives, Inc | $17.1K | 1 | | |
| 211 | E Fund Management (Hong Kong) Co., Ltd. | $14.3K | 1 | | |
| 212 | True Wealth Design, LLC | $13.1K | 1 | | |
| 213 | Smartleaf Asset Management LLC | $7.9K | 1 | | |
| 214 | SMA Capital LLC | $6.2K | 1 | | |
| 215 | Larson Financial Group LLC | $5.9K | 1 | | |
| 216 | FIFTH THIRD BANCORP | $4.2K | 1 | | |
| 217 | Spire Wealth Management | $3.4K | 1 | | |
| 218 | SBI Securities Co., Ltd. | $3.0K | 1 | | |
| 219 | Vermillion Wealth Management, Inc. | $2.3K | 1 | | |
| 220 | Steward Partners Investment Advisory, LLC | $2.2K | 1 | | |
| 221 | Decker Retirement Planning Inc. | $2.2K | 1 | | |
| 222 | Allworth Financial LP | $1.7K | 1 | | |
| 223 | WPG Advisers, LLC | $1.7K | 1 | | |
| 224 | ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ | $1.1K | 1 | | |
| 225 | Parkside Financial Bank & Trust | $1.1K | 1 | | |
| 226 | JPL Wealth Management, LLC | $1.0K | 1 | | |
| 227 | HARBOR CAPITAL ADVISORS, INC. | $777 | 1 | | |
| 228 | ALGERT GLOBAL LLC | $647 | 1 | | |
| 229 | GSA CAPITAL PARTNERS LLP | $479 | 1 | | |
| 230 | MAI Capital Management | $457 | 1 | | |
| 231 | ACADIAN ASSET MANAGEMENT LLC | $344 | 1 | | |
| 232 | TEALWOOD ASSET MANAGEMENT INC | $212 | 1 | | |
| 233 | Stone House Investment Management, LLC | $114 | 1 | | |
| 234 | KBC Group NV | $64 | 1 | | |
| 235 | TRUIST FINANCIAL CORP | — value not disclosed | 1 | | |
| 236 | Jefferies Financial Group Inc. | — value not disclosed | 1 | | |
| 237 | VANGUARD GROUP INC | — value not disclosed | 1 | | |
| 238 | MEEDER ASSET MANAGEMENT INC | — value not disclosed | 1 | | |
| 239 | HSBC HOLDINGS PLC | — value not disclosed | 1 | | |
| 240 | COMERICA BANK | — value not disclosed | 1 | | |
| 241 | AMALGAMATED BANK | — value not disclosed | 1 | | |
| 242 | ORBIMED ADVISORS LLC | — value not disclosed | 1 | | |
| 243 | CIBC WORLD MARKETS CORP | — value not disclosed | 1 | | |
| 244 | CIBC Private Wealth Group LLC | — value not disclosed | 1 | | |
| 245 | Graham Capital Management, L.P. | — value not disclosed | 1 | | |
| 246 | NORGES BANK | — value not disclosed | 1 | | |
| 247 | PRELUDE CAPITAL MANAGEMENT, LLC | — value not disclosed | 1 | | |
| 248 | Blackstone Inc. | — value not disclosed | 1 | | |
| 249 | PUBLIC SECTOR PENSION INVESTMENT BOARD | — value not disclosed | 1 | | |
| 250 | J. Goldman & Co LP | — value not disclosed | 1 | | |
| 251 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | — value not disclosed | 1 | | |
| 252 | BOOTHBAY FUND MANAGEMENT, LLC | — value not disclosed | 1 | | |
| 253 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | — value not disclosed | 1 | | |
| 254 | Aristides Capital LLC | — value not disclosed | 1 | | |
| 255 | Trexquant Investment LP | — value not disclosed | 1 | | |
| 256 | DV Trading LLC | — value not disclosed | 1 | | |
| 257 | AIGEN INVESTMENT MANAGEMENT, LP | — value not disclosed | 1 | | |
| 258 | Global Retirement Partners, LLC | — value not disclosed | 1 | | |
| 259 | Ikarian Capital, LLC | — value not disclosed | 1 | | |
| 260 | Aquatic Capital Management LLC | — value not disclosed | 1 | | |
| 261 | Everhart Financial Group, Inc. | — value not disclosed | 1 | | |
| 262 | AlphaQuest LLC | — value not disclosed | 1 | | |
| 263 | Nearwater Capital Markets, Ltd | — value not disclosed | 1 | | |
| 264 | Polymer Capital Management (US) LLC | — value not disclosed | 1 | | |
| 265 | NEOS Investment Management LLC | — value not disclosed | 1 | | |
| 266 | Exome Asset Management LLC | — value not disclosed | 1 | | |
| 267 | Avanza Fonder AB | — value not disclosed | 1 | | |