RTW INVESTMENTS, LP

$10.0B reported 13(f) long value · latest quarter 2026-03-31 · CIK 1493215 · EDGAR ↗

sum of disclosed values for 2026-03-31; 0 positions carry a NULL value and are excluded from the sum, surfaced here rather than folded away: $10.0B
ALL retained default holdings for this (filer, period), including NULL-value ones: 88
positions with no comparable holding in the prior quarter (kind new), 2026-03-31: 9
positions absent from this quarter's filing after being held last quarter (kind exit), 2026-03-31 — inferred from absence, not a sale record: 12

A quarter-end snapshot. Filed up to 45 days later, so this page is not current holdings and never a complete portfolio. what a 13F is — and is not ↓ methodology §13F ↗

Position changes — into 2026-03-31

by shares · Δ value · filing link · how changes are classified §

Position changes into quarter 2026-03-31
position matched across quarters by exact reported CUSIP over a registry gap — producer-reconciled identity, never a name match `identity_reconciled_by_cusip`	the reported share count is unchanged across the pair; this build's data classified the change from its reported value; builds from 2026-09-10 on read it as NO CHANGE `classified_by_value` · EXIT = absent this quarter: disposed, delisted, under confidential treatment, or reported instead by an affiliated manager — the filing does not say which · change not classifiable: value undisclosed on one side of the quarter pair, or neither shares nor value can classify it · NO CHANGE = the share count is identical in both quarters; the value moved only with price, so the row is mark-to-market and never an ADD or a TRIM (NEW / ADD / TRIM / EXIT / NO CHANGE) · NO PRIOR = this filer has no comparable holdings list for the previous quarter on record — a first filing under this registration, or a quarter reported inside an affiliated manager's filing — so the position is not called a new stake	derived by Public Filings from the published aggregate; NULL means the source did not disclose a usable value — never zero	reported unit changed across the pair (SH↔PRN); the share delta is withheld rather than fabricated `shares_unit_mismatch`	Prev value	Curr value	Prev shares	Curr shares
position key `pos:14207` · issuer key `iss:973` COM PAR $.01	ADD	−$50.9M	+1	$843M	$792M	4,842,879	4,842,880
position key `pos:17260` · issuer key `iss:165` SPONSORED ADR	ADD	−$48.3M	+35,949	$566M	$518M	673,497	709,446
position key `pos:11549` · issuer key `iss:429` COM	ADD	+$389M	+4,972,681	$83.5M	$473M	2,012,127	6,984,808
position key `pos:10390` · issuer key `iss:416` COM	ADD	+$292M	+2,489,461	$54.9M	$347M	550,160	3,039,621
position key `pos:11535` · issuer key `iss:1757` COM	ADD	+$265M	+11,809,392	$13.2M	$278M	1,491,228	13,300,620
position key `pos:11747` · issuer key `iss:680` COM	ADD	+$261M	+16,010,524	$546K	$261M	146,651	16,157,175
position key `pos:13186` · issuer key `iss:1273` COM	TRIM	−$93.6M	−250,000	$344M	$250M	1,500,000	1,250,000
position key `pos:11138` · issuer key `iss:1519` COM	ADD	−$41.5M	+346,500	$281M	$239M	3,938,500	4,285,000
position key `pos:10610` · issuer key `iss:1761` COM	ADD	−$38.4M	+10,705	$273M	$235M	3,335,320	3,346,025
position key `pos:13239` · issuer key `iss:142` COM	ADD	+$29.5M	+70,000	$205M	$234M	2,712,097	2,782,097
position key `pos:17421` · issuer key `iss:475` COM	TRIM	−$59.6M	−2,133,566	$270M	$210M	7,592,241	5,458,675
position key `pos:12344` · issuer key `iss:946` COM	ADD	−$12.8M	+486,510	$210M	$197M	1,181,990	1,668,500
position key `sid:sec:prov:3fee4169345e05a49cf14bcc2babfc71` · issuer key `cusip6:86150R` COM	ADD	+$7.0M	+76,669	$176M	$183M	5,546,856	5,623,525
position key `sid:sec:prov:7bf59fd7aeffb1ecf2ffdacd97c7e39d` · issuer key `cusip6:G31249` COM	ADD	−$37.9M	+66,864	$189M	$151M	2,588,831	2,655,695
position key `sid:sec:prov:233302be8852a126d4f3dc726082a4c4` · issuer key `cusip6:03753U` COM	TRIM	−$44.3M	−3,981,719	$193M	$148M	7,666,764	3,685,045
position key `pos:12597` · issuer key `iss:1545` COM	ADD	−$32.3M	+142,000	$174M	$142M	1,064,000	1,206,000
position key `sid:sec:prov:8771e17f16590b5bd511978f2a4f7807` · issuer key `cusip6:N44445` SHS	ADD	+$6.6M	+1,435,986	$120M	$127M	11,433,354	12,869,340
position key `pos:13828` · issuer key `cusip6:98887Q` ADR	TRIM	+$900K	−385,000	$123M	$124M	6,959,032	6,574,032
position key `pos:16805` · issuer key `iss:997` COM NEW	ADD	+$44.1M	+118,772	$57.3M	$101M	101,228	220,000
position key `pos:17964` · issuer key `cusip6:152309` SPONSORED ADS	ADD	+$36.8M	+263,338	$44.8M	$81.6M	1,790,837	2,054,175
position key `sid:sec:prov:c0680e314bfe2d1131f5c3d642c67920` · issuer key `cusip6:45258J` COM	TRIM	−$1.8M	−1	$80.8M	$78.9M	3,177,850	3,177,849
position key `pos:15677` · issuer key `iss:1851` COM	ADD	+$7.4M	+648,656	$69.0M	$76.4M	3,000,139	3,648,795
position key `sid:sec:prov:15b122a1959cdc720dffb69686bc9994` · issuer key `cusip6:433313` CL A	ADD	+$58.0M	+1,576,500	$16.4M	$74.4M	353,500	1,930,000
position key `sid:sec:prov:fd9590ea03898824f7f15a013603f826` · issuer key `cusip6:14843C` COM	ADD	−$14.6M	+643,098	$82.3M	$67.7M	2,115,237	2,758,335
position key `pos:13793` · issuer key `iss:1763` COM SHS	TRIM	−$29.0M	−2,718,049	$90.2M	$61.2M	16,398,297	13,680,248
position key `sid:sec:prov:88f799da4526ad1ae0a440740a6e9c1b` · issuer key `cusip6:20451W` SPONSORED ADS	ADD	−$1.6M	+1,875,000	$60.4M	$58.8M	8,757,390	10,632,390
position key `sid:sec:prov:b6301632224d8122ae8dff0115962cfa` · issuer key `cusip6:50015M` COM	ADD	+$15.1M	+1	$41.6M	$56.7M	1,487,933	1,487,934
position key `pos:12518` · issuer key `iss:1547` COM	ADD	−$13.1M	+216,564	$69.4M	$56.3M	7,140,352	7,356,916
position key `pos:14981` · issuer key `iss:535` COM	ADD	−$10.2M	+100,000	$62.9M	$52.7M	1,351,326	1,451,326
position key `pos:11075` · issuer key `iss:2299` SHS	TRIM	−$46.5M	−1,125,106	$88.8M	$42.3M	3,711,462	2,586,356
position key `pos:15030` · issuer key `iss:1951` COM	NEW	+$39.3M	+1,630,000	$0	$39.3M	—	1,630,000
position key `pos:15725` · issuer key `iss:172` COM	ADD	−$2.1M	+966	$38.8M	$36.7M	584,716	585,682
position key `sid:sec:prov:adbff6ad799c41f5a1fe4cddc6ffc42b` · issuer key `cusip6:30054Y` COM SHS	ADD	+$12.6M	+218,564	$22.0M	$34.5M	1,283,671	1,502,235
position key `pos:15220` · issuer key `iss:1725` COM	TRIM	−$53.3M	−145,000	$86.1M	$32.9M	245,000	100,000
position key `sid:sec:prov:36c1cc87b96fff749fa3a87e5be52946` · issuer key `cusip6:137404` COM	NEW	+$31.5M	+6,422,018	$0	$31.5M	—	6,422,018
position key `sid:sec:prov:287679ae59495e28d5c5c22eea9bb86e` · issuer key `cusip6:03843E` COM	ADD	−$9.6M	+1,176,471	$40.4M	$30.8M	6,250,000	7,426,471
position key `pos:10215` · issuer key `iss:62` COM	NEW	+$28.5M	+1,592,043	$0	$28.5M	—	1,592,043
position key `sid:sec:prov:c5f3f37de4d48fd1b29c266e9a76eb0b` · issuer key `cusip6:20454B` COM	ADD	+$8.7M	+1,686,599	$13.4M	$22.1M	2,500,000	4,186,599
position key `pos:17547` · issuer key `iss:577` COM	NEW	+$20.8M	+248,063	$0	$20.8M	—	248,063
position key `pos:13978` · issuer key `iss:784` COM	ADD	+$2.0M	+583,973	$18.5M	$20.5M	705,027	1,289,000
position key `sid:sec:prov:4e7eb09ab13c64fd6730ede8dbc988b8` · issuer key `cusip6:08659B` COM	TRIM	−$56.1M	−500,000	$76.2M	$20.0M	2,500,000	2,000,000
position key `sid:sec:prov:310355a827423f86fff2dece8e909dcb` · issuer key `cusip6:15673T` COM	NEW	+$19.7M	+8,695,652	$0	$19.7M	—	8,695,652
position key `sid:sec:prov:37b91915f07af95197894a79df85a91e` · issuer key `cusip6:05338F` COM NEW	NEW	+$12.8M	+856,962	$0	$12.8M	—	856,962
position key `sid:sec:prov:748132ab3b87c3f18391f70e454d8e10` · issuer key `cusip6:67577C` COM	NEW	+$12.1M	+6,666,666	$0	$12.1M	—	6,666,666
position key `sid:sec:prov:3b4a08cf659449a1ac1d2ee41e501b50` · issuer key `cusip6:008064` COM NEW	TRIM	−$14.3M	−876,068	$22.4M	$8.1M	1,449,273	573,205
position key `sid:sec:prov:22b723f52f71593881ef80163fb7daf8` · issuer key `cusip6:59935V` COM	ADD	+$2.5M	+3,824,899	$5.1M	$7.5M	2,506,102	6,331,001
position key `sid:sec:prov:36f6260da0bf69546f0e601e6d5bafdc` · issuer key `cusip6:46124U` ADS	ADD	+$1.2M	+1	$6.0M	$7.2M	1,298,701	1,298,702
position key `pos:12610` · issuer key `iss:183` COM SHS	NEW	+$7.1M	+2,000,000	$0	$7.1M	—	2,000,000
position key `sid:sec:prov:853ca021ff04669801b685877f2dabbb` · issuer key `cusip6:517125` COM	TRIM	−$5.2M	−1,625,000	$11.9M	$6.8M	3,125,000	1,500,000
position key `sid:sec:prov:9e958f4e10d0d474cc9e75d42ea33a9a` · issuer key `cusip6:88032L` COM NEW	TRIM	+$1.3M	−8,100	$4.6M	$5.9M	378,346	370,246
position key `pos:16675` · issuer key `iss:563` COM SHS	NEW	+$5.7M	+300,000	$0	$5.7M	—	300,000
position key `sid:sec:prov:6cea3d644720599797447228551acb50` · issuer key `cusip6:30068X` COM	TRIM	−$3.6M	−395,231	$4.8M	$1.2M	790,462	395,231
pos:10385	EXIT‡e	−$269M	−866,499	$269M	$0	866,499	—
pos:12780	EXIT‡e	−$11.8M	−200,000	$11.8M	$0	200,000	—
pos:13067	EXIT‡e	−$162M	−888,001	$162M	$0	888,001	—
pos:16495	EXIT‡e	−$10.4M	−46,000	$10.4M	$0	46,000	—
pos:17234	EXIT‡e	−$92.3M	−324,600	$92.3M	$0	324,600	—
sid:sec:prov:003ec1a792a63a6ca1608977e0029001	EXIT‡e	−$88.9M	−683,294	$88.9M	$0	683,294	—
sid:sec:prov:0983c227d7f489fadce1abda0a417532	EXIT‡e	−$55.5M	−1,637,165	$55.5M	$0	1,637,165	—
sid:sec:prov:3044f98940a2897deb445091c04637d0	EXIT‡e	−$4.0M	−300,000	$4.0M	$0	300,000	—
sid:sec:prov:7cea07f55574bfdadadb6c74621338ac	EXIT‡e	−$8.2M	−2,000,000	$8.2M	$0	2,000,000	—
sid:sec:prov:862b191ccb923fc424f39385b48ce4f8	EXIT‡e	−$7.0M	−100,000	$7.0M	$0	100,000	—
sid:sec:prov:990effbc09610fc927e1edc54d252d9d	EXIT‡e	−$3.4M	−447,607	$3.4M	$0	447,607	—
sid:sec:prov:c788d5d7e7e35880122f2fe6fcd2b7b8	EXIT‡e	−$7.2M	−5,891,430	$7.2M	$0	5,891,430	—

Flags: no row carries a flag.

1–20 of the 64 changes on this page

Mark-to-market only (no share change) · 36

Positions whose share count is identical in both quarters; the value changed with price, not with a decision.

Positions held with no share change into quarter 2026-03-31
position matched across quarters by exact reported CUSIP over a registry gap — producer-reconciled identity, never a name match `identity_reconciled_by_cusip`	the reported share count is unchanged across the pair; this build's data classified the change from its reported value; builds from 2026-09-10 on read it as NO CHANGE `classified_by_value` · EXIT = absent this quarter: disposed, delisted, under confidential treatment, or reported instead by an affiliated manager — the filing does not say which · change not classifiable: value undisclosed on one side of the quarter pair, or neither shares nor value can classify it · NO CHANGE = the share count is identical in both quarters; the value moved only with price, so the row is mark-to-market and never an ADD or a TRIM (NEW / ADD / TRIM / EXIT / NO CHANGE) · NO PRIOR = this filer has no comparable holdings list for the previous quarter on record — a first filing under this registration, or a quarter reported inside an affiliated manager's filing — so the position is not called a new stake	derived by Public Filings from the published aggregate; NULL means the source did not disclose a usable value — never zero	Prev value	Curr value	Prev shares	Curr shares
position key `pos:14357` · issuer key `iss:1170` COM	NO CHANGE	−$117M	$1.2B	$1.0B	1,993,687	1,993,687
position key `pos:13950` · issuer key `iss:1497` COM	NO CHANGE	+$91.4M	$442M	$533M	5,059,053	5,059,053
position key `pos:17611` · issuer key `iss:1399` COM	NO CHANGE	−$60.7M	$588M	$528M	7,746,415	7,746,415
position key `pos:13625` · issuer key `iss:45` COM NEW	NO CHANGE	+$73.8M	$137M	$210M	4,171,996	4,171,996
position key `pos:12465` · issuer key `iss:548` COM NEW	NO CHANGE	+$6.4M	$173M	$179M	2,721,158	2,721,158
position key `pos:17971` · issuer key `iss:30` COM	NO CHANGE	−$31.8M	$191M	$159M	7,144,524	7,144,524
position key `pos:15541` · issuer key `iss:958` ADS	NO CHANGE	−$22.2M	$169M	$147M	4,869,798	4,869,798
position key `pos:11462` · issuer key `iss:1296` COM	NO CHANGE	−$10.7M	$151M	$140M	1,062,072	1,062,072
position key `pos:17626` · issuer key `iss:860` COM	NO CHANGE	−$14.5M	$151M	$137M	1,481,033	1,481,033
position key `sid:sec:prov:831c753eb8a6ce9972092ec4165601d4` · issuer key `cusip6:07782B` SPONSORED ADS	NO CHANGE	−$372K	$114M	$114M	715,332	715,332
position key `pos:13812` · issuer key `iss:1378` COM	NO CHANGE	+$38.6M	$62.4M	$101M	2,058,148	2,058,148
position key `sid:sec:prov:592cbdfa12c811cc697874a89333d4bb` · issuer key `cusip6:G3855L` ORDINARY SHARES	NO CHANGE	+$8.1M	$75.4M	$83.4M	5,933,815	5,933,815
position key `sid:sec:prov:bc17a1945987420f684d9107b41fd336` · issuer key `cusip6:98401F` COM	NO CHANGE	−$22.0M	$104M	$81.7M	6,777,461	6,777,461
position key `sid:sec:prov:a469da6cabfc03832e3d85a7bff09e97` · issuer key `cusip6:M96088` COM	NO CHANGE	−$24.7M	$106M	$81.7M	4,543,895	4,543,895
position key `sid:sec:prov:5db085c4e925ed01a4a1cbc6ba09d304` · issuer key `cusip6:77313F` COM	NO CHANGE	+$1.2M	$62.1M	$63.3M	17,687,772	17,687,772
position key `pos:15525` · issuer key `iss:2023` SHS	NO CHANGE	+$12.3M	$46.8M	$59.1M	1,672,356	1,672,356
position key `sid:sec:prov:9f123b52d9dfa5657af06135ef52f112` · issuer key `cusip6:68572M` COM	NO CHANGE	+$831K	$34.5M	$35.3M	8,306,063	8,306,063
position key `pos:13163` · issuer key `cusip6:92337C` COM NEW	NO CHANGE	−$15.9M	$50.8M	$34.9M	6,576,306	6,576,306
position key `sid:sec:prov:2bc6a25d40cf07124e3a03bdecf4a4df` · issuer key `cusip6:805111` COM	NO CHANGE	−$3.4M	$35.9M	$32.5M	5,952,380	5,952,380
position key `sid:sec:prov:2436d0e4b9db5d946b26deb83a717d5e` · issuer key `cusip6:64135M` COM	NO CHANGE	−$599K	$28.1M	$27.5M	1,362,456	1,362,456
position key `pos:12625` · issuer key `iss:544` COM	NO CHANGE	+$6.6M	$17.7M	$24.2M	1,705,960	1,705,960
position key `pos:12598` · issuer key `iss:1082` COM	NO CHANGE	+$1.3M	$18.7M	$20.0M	240,000	240,000
position key `sid:sec:prov:fbdfb263adbfc86bd605b695db4205d4` · issuer key `cusip6:07373V` COM	NO CHANGE	−$2.2M	$15.8M	$13.6M	570,394	570,394
position key `sid:sec:prov:5c9dafc33c07d8edc9231c0ecacc39e5` · issuer key `cusip6:42238D` COM	NO CHANGE	−$2.4M	$14.4M	$12.0M	495,000	495,000
position key `pos:14281` · issuer key `iss:2313` SHS	NO CHANGE	−$13.2M	$23.0M	$9.8M	1,350,000	1,350,000
position key `pos:15905` · issuer key `iss:2186` CL A ORD SHS	NO CHANGE	−$1.5M	$9.7M	$8.1M	742,500	742,500
position key `sid:sec:prov:f5ab5fc62f8ffc42012ac685dc8651c0` · issuer key `cusip6:14070B` COM NEW	NO CHANGE	+$385K	$7.2M	$7.6M	250,000	250,000
position key `pos:11729` · issuer key `cusip6:482929` COM	NO CHANGE	−$3.5M	$11.0M	$7.5M	1,300,000	1,300,000
position key `pos:16706` · issuer key `iss:2081` COM	NO CHANGE	+$2.4M	$4.4M	$6.8M	372,856	372,856
position key `sid:sec:prov:9e0f507ae4c750638fbe313997f8baa5` · issuer key `cusip6:550249` COM	NO CHANGE	−$6.4M	$12.0M	$5.6M	650,000	650,000
position key `sid:sec:prov:adc22e9a1524ab89aa68e69a21eb8d93` · issuer key `cusip6:35104E` COM	NO CHANGE	+$861K	$3.6M	$4.4M	475,737	475,737
position key `pos:15409` · issuer key `iss:1212` COM CL A	NO CHANGE	+$175K	$2.9M	$3.1M	70,000	70,000
position key `sid:sec:prov:748c3ea2043f7dae881221f3c766e002` · issuer key `cusip6:68170A` COM	NO CHANGE	−$642K	$3.2M	$2.5M	200,000	200,000
position key `pos:12161` · issuer key `iss:587` COM	NO CHANGE	−$464K	$2.4M	$1.9M	30,000	30,000
position key `sid:sec:prov:6db6b47119928ad4af3cf49015c9c5eb` · issuer key `cusip6:45175G` COM	NO CHANGE	−$635K	$2.3M	$1.7M	334,445	334,445
position key `sid:sec:prov:2e0b7c193ae04d1491f7555c4c197a31` · issuer key `cusip6:77313F` *W EXP 09/02/202	NO CHANGE	−$1.3K	$8.5K	$7.2K	350,000	350,000

Flags: no row carries a flag.

Newest filing in this build: 2026-07-31. Per-row filing dates are on each receipt.

Truncated by Public Filings. Changes compare every position with a security identifier, new and exited included; holdings without one are counted, not compared. methodology §13F ↗

Reported positions — 2026-03-31

1–87 of 87 issuers · $10.0B disclosed value over 88 rows · 0 undisclosed-value rows

View

This build carries one quarter for this manager: 2026-03-31. Notable managers carry four published quarters, others two.

This list carries reported issuer names and security identities, without a dated ticker mapping. Symbols are not inferred from names.

a position composed from a base filing plus NEW-HOLDINGS amendments keeps every source row here; the composition's latest filed date is the one shown served from this build's published holdings (derived from the filer's own reported rows); every row resolves to its filing

Share of total reported value, calculated only when the full position list has disclosed values. This is 13F long value, not total assets.

value undisclosed on the filing: retained and counted, excluded from sums, never shown as $0

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

MADRIGAL PHARMACEUTICALS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$1.0B

1,993,687

10.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

INSMED INC · COM PAR $.01 CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$792M

4,842,880

7.9%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

PROTAGONIST THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$533M

5,059,053

5.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

PTC THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$528M

7,746,415

5.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ARGENX SE · SPONSORED ADR CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$518M

709,446

5.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CG ONCOLOGY INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$473M

6,984,808

4.7%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CELCUITY INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$347M

3,039,621

3.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

TANGO THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$278M

13,300,620

2.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ERASCA INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$261M

16,157,175

2.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

NATERA INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$250M

1,250,000

2.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

RADNET INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$239M

4,285,000

2.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

TARSUS PHARMACEUTICALS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$235M

3,346,025

2.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

APOGEE THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$234M

2,782,097

2.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

SPYRE THERAPEUTICS INC · COM NEW CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$210M

4,171,996

2.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

COGENT BIOSCIENCES INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$210M

5,458,675

2.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

IRHYTHM HOLDINGS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$197M

1,668,500

2.0%

—

STOKE THERAPEUTICS INC · COM CUSIP 86150R107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$183M

5,623,525

1.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CYTOKINETICS INC · COM NEW CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$179M

2,721,158

1.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ACADIA PHARMACEUTICALS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$159M

7,144,524

1.6%

—

ESTABLISHMENT LABS HLDGS INC · COM CUSIP G31249108
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$151M

2,655,695

1.5%

—

APELLIS PHARMACEUTICALS INC · COM CUSIP 03753U106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$148M

3,685,045

1.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

IMMUNOCORE HLDGS PLC · ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$147M

4,869,798

1.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

REPLIGEN CORP · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$142M

1,206,000

1.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

NEUROCRINE BIOSCIENCES INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$140M

1,062,072

1.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

GUARDANT HEALTH INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$137M

1,481,033

1.4%

—

IMMATICS N.V · SHS CUSIP N44445109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$127M

12,869,340

1.3%

—

ZAI LAB LTD · ADR CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$124M

6,574,032

1.2%

—

BELITE BIO INC · SPONSORED ADS CUSIP 07782B104
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$114M

715,332

1.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

INTUITIVE SURGICAL INC · COM NEW CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$101M

220,000

1.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ORUKA THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$101M

2,058,148

1.0%

—

GH RESEARCH PLC · ORDINARY SHARES CUSIP G3855L106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$83.4M

5,933,815

0.8%

—

XENCOR INC · COM CUSIP 98401F105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$81.7M

6,777,461

0.8%

—

UROGEN PHARMA LTD · COM CUSIP M96088105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$81.7M

4,543,895

0.8%

—

CENTESSA PHARMACEUTICALS PLC · SPONSORED ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$81.6M

2,054,175

0.8%

—

IMMUNOVANT INC · COM CUSIP 45258J102
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$78.9M

3,177,849

0.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ULTRAGENYX PHARMACEUTICAL IN · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$76.4M

3,648,795

0.8%

—

HINGE HEALTH INC · CL A CUSIP 433313103
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$74.4M

1,930,000

0.7%

—

CASTLE BIOSCIENCES INC · COM CUSIP 14843C105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$67.7M

2,758,335

0.7%

—

ROCKET PHARMACEUTICALS INC

2 positions · 2 reported rows

Rows RTW INVESTMENTS, LP reported for ROCKET PHARMACEUTICALS INC, as it reported them
ROCKET PHARMACEUTICALS INC · COM CUSIP 77313F106 src ↗	$63.3M	17,687,772
ROCKET PHARMACEUTICALS INC · *W EXP 09/02/202 CUSIP 77313F114 src ↗	$7.2K	350,000

ticker not yet mapped

$63.3M

18,037,772

0.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

TAYSHA GENE THERAPIES INC · COM SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$61.2M

13,680,248

0.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ALKERMES PLC · SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$59.1M

1,672,356

0.6%

—

COMPASS PATHWAYS PLC · SPONSORED ADS CUSIP 20451W101
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$58.8M

10,632,390

0.6%

—

KODIAK SCIENCES INC · COM CUSIP 50015M109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$56.7M

1,487,934

0.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

REPLIMUNE GROUP INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$56.3M

7,356,916

0.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CRINETICS PHARMACEUTICALS IN · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$52.7M

1,451,326

0.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

UNIQURE NV · SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$42.3M

2,586,356

0.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

WAYSTAR HLDG CORP · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$39.3M

1,630,000

0.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ARROWHEAD PHARMACEUTICALS IN · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$36.7M

585,682

0.4%

—

ORCHESTRA BIOMED HLDGS INC · COM CUSIP 68572M106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$35.3M

8,306,063

0.4%

—

VERASTEM INC · COM NEW CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$34.9M

6,576,306

0.3%

—

EVOMMUNE INC · COM SHS CUSIP 30054Y107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$34.5M

1,502,235

0.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

STRYKER CORPORATION · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$32.9M

100,000

0.3%

—

SAVARA INC · COM CUSIP 805111101
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$32.5M

5,952,380

0.3%

—

CANDEL THERAPEUTICS INC · COM CUSIP 137404109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$31.5M

6,422,018

0.3%

—

AQUESTIVE THERAPEUTICS INC · COM CUSIP 03843E104
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$30.8M

7,426,471

0.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

AKTIS ONCOLOGY INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$28.5M

1,592,043

0.3%

—

NEUROGENE INC · COM CUSIP 64135M105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$27.5M

1,362,456

0.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CULLINAN THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$24.2M

1,705,960

0.2%

—

COMPASS THERAPEUTICS INC · COM CUSIP 20454B104
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$22.1M

4,186,599

0.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

DIANTHUS THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$20.8M

248,063

0.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

FULGENT GENETICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$20.5M

1,289,000

0.2%

—

BETA BIONICS INC · COM CUSIP 08659B102
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$20.0M

2,000,000

0.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

KYMERA THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$20.0M

240,000

0.2%

—

CENTURY THERAPEUTICS INC · COM CUSIP 15673T100
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$19.7M

8,695,652

0.2%

—

BEAM THERAPEUTICS INC · COM CUSIP 07373V105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$13.6M

570,394

0.1%

—

AVALO THERAPEUTICS INC · COM NEW CUSIP 05338F306
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$12.8M

856,962

0.1%

—

OCUGEN INC · COM CUSIP 67577C105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$12.1M

6,666,666

0.1%

—

HEARTFLOW INC · COM CUSIP 42238D107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$12.0M

495,000

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

WAVE LIFE SCIENCES LTD · SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$9.8M

1,350,000

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

PERCEPTIVE CAP SOLUTIONS COR · CL A ORD SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$8.1M

742,500

0.1%

—

JADE BIOSCIENCES INC · COM NEW CUSIP 008064206
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$8.1M

573,205

0.1%

—

CAPRICOR THERAPEUTICS INC · COM NEW CUSIP 14070B309
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$7.6M

250,000

0.1%

—

MILESTONE PHARMACEUTICALS IN · COM CUSIP 59935V107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$7.5M

6,331,001

0.1%

—

KALARIS THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$7.5M

1,300,000

0.1%

—

INVENTIVA SA · ADS CUSIP 46124U107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$7.2M

1,298,702

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ATAIBECKLEY INC · COM SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$7.1M

2,000,000

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CRESCENT BIOPHARMA INC. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$6.8M

372,856

0.1%

—

LARIMAR THERAPEUTICS INC · COM CUSIP 517125100
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$6.8M

1,500,000

0.1%

—

TENAX THERAPEUTICS INC · COM NEW CUSIP 88032L605
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$5.9M

370,246

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

DEFINIUM THERAPEUTICS INC · COM SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$5.7M

300,000

0.1%

—

LUMEXA IMAGING HOLDINGS INC · COM CUSIP 550249106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$5.6M

650,000

0.1%

—

4D MOLECULAR THERAPEUTICS IN · COM CUSIP 35104E100
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$4.4M

475,737

0.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

MEDLINE INC · COM CL A CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$3.1M

70,000

0.0%

—

OMADA HEALTH INC · COM CUSIP 68170A108
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$2.5M

200,000

0.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

DISC MEDICINE INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$1.9M

30,000

0.0%

—

IMAGENEBIO INC · COM CUSIP 45175G207
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$1.7M

334,445

0.0%

—

EXAGEN INC · COM CUSIP 30068X103
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$1.2M

395,231

0.0%

1–20 of 87 issuers

Change kind and share change are in Position changes above; Congress overlap is planned.

One line per issuer, largest first; a row with no issuer key stands on its own line. Open a line for its rows as this filer reported them. The list holds every row this filer reported for the quarter. Issuer totals on the holders pages count each manager's own report once; that never removes a row here. how positions are grouped ↗

Book shape

2026-03-31 · concentration · vs tracked median · tick = median

Top-25 concentration: 77.0%below median 80.0%
Concentration index: 372 bpsbelow median 446 bps
Positions with value: 88 / 88median book 97.5 positions

Concentration uses reported 13F long value, not total assets. The index is withheld when any position lacks a value. Medians are over the 8,748 tracked filers with a 2026-03-31 book; the index median over the 8,662 with a complete book.

holdings whose <value> did not parse — retained and counted, never zero-filled: 0 · share of the period's disclosed value held in the top-N positions; denominator is reported 13F value, not total assets: 77.0% · integer Herfindahl–Hirschman index in basis points over disclosed position values: 372 · QoQ moves: 100

Filing history

AVAILABLE QUARTERS

Available filing periods
Period	Source
2026-03-31	EDGAR ↗

PLANNED sector rotation · Congress overlap · signals for this filer

Complete source filings on SEC EDGAR

The complete filing on EDGAR.

The position list above is served from the published Public Filings build, each position as this filer reported it; where the page cannot embed every reported row, the list says how many it leaves out. This block is provenance, not a substitute: the filing itself is the record, and it is one click away. Public Filings decided on 2026-08-01 to serve this list from its published build; filings newer than this build are on EDGAR.

Open RTW INVESTMENTS, LP's 13F filings on SEC EDGAR ↗

Notes on this data

Reported positions

Quarter-end holdings as filed

Explore the full published position list and its source filing. This record excludes the manager’s cash, shorts and non-13(f) assets.

Share changes

Compare consecutive quarters

Position changes retain the producer’s classification and comparability flags. Share counts and reported values describe different changes.

Coverage

A snapshot, not current holdings

Use the quarter selector to inspect available periods. Unknown values stay unknown and each table states its coverage.

A 13F is a quarterly, long-only snapshot filed up to 45 days late — not current holdings. what a 13F covers ↗

13F reports cover LONG positions in Section 13(f) securities (US exchange-traded equities plus reportable options, warrants, certain convertibles) held by managers with at least $100M in such securities — so managers below that threshold are absent entirely. No short positions, no cash, no non-13(f) assets — not a full portfolio, and not a census of institutional ownership.

Positions are quarter-end snapshots filed up to 45 days late — not current holdings. A position may have been changed or closed before you ever see it, and is older still by however long ago that quarter ended.

Values are the manager's stated market value at quarter-end in era-dependent units (whole dollars for form versions effective 2023-01-03 onward, thousands before), normalized here to whole dollars with unit_basis carried on every record.

Affiliated managers may report the same position (otherManager), so one position can appear under more than one filer.

Positions under confidential treatment may be omitted until a later amendment discloses them.

These are disclosures, not investment advice (ARCHITECTURE.md §5.2 / M2-CONTRACT §5).